Fig. 1

MeDeCom deconvolves subtype-specific methylation patterns. Proportions for the deconvolution of TCGA-SARC methylation data using 9 LMCs and λ = 0.01 are shown. Unsupervised deconvolution based on non-negative matrix factorization resulted in methylation components associated with histological subtypes and tumor tissue sites. LMS, leiomyosarcoma; DDLPS, dedifferentiated liposarcoma; MFS, myxofibrosarcoma; UPS, undifferentiated pleomorphic sarcoma; SS, synovial sarcoma; MPNST, malignant peripheral nerve sheath tumor