Fig. 2

Protocol of dosage of heparin. Extracorporeal membrane oxygenation was started after the activated clotting time (ACT) level reached 180–250 s. First, 50 IU/kg heparin was bolused, and the ACT level was measured after 5 min. If the ACT level was less than 150 s, another 50 IU/kg heparin was rebolused. If the ACT level was between 150 and 170 s, another 25 IU/kg heparin was rebolused. If the ACT level was between 170 and 180 s, another 12.5 IU/kg heparin was rebolused