Fig. 6

Prognosis and therapeutic strategies according to immune classes. a Kaplan–Meier plots of overall survival according to the immune and non-immune classes. b Kaplan–Meier plots of overall survival according to the active immune, exhausted, and non-immune classes. c Kaplan–Meier plots of overall survival according to the exhausted and non-exhausted classes before and after adjustment for risk factors. d The expression of PDCD1 and CTLA4 was significantly upregulated in the active immune class compared with the other classes. e Immunophenoscore (IPS) of patients under anti-CTLA4 treatment in the active immune, exhausted, and non-immune classes. f Chemosensitivity according to the active immune, exhausted, and non-immune classes. The drugs with red box are used for First- and second-line treatment in CCs. g The expression of EGFR was significantly upregulated in the exhausted class compared with the other classes. *p < 0.05; **p < 0.01; ***p < 0.001