Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignancies

Table 4 Multivariate analysis of the severity disease indexes that showed the highest significant differences at the univariate analysis

Severity disease indexes	R²	95% confidence interval	Standard error	P value
Hemocromocytometric and flow cytometry
WBC	0.99	− 0.26 to 0.66	0.23	< 0.0001
ANC	0.99	− 0.73 to 0.21	0.23
ALC	0.97	− 0.73 to 0.25	0.24
CD3+	0.99	− 0.01 to 0.01	0.01
CD45+CD3+CD8+	0.96	− 0.01 to 0.01	0.01
CD45+CD3+CD4+	0.99	− 0.01 to 0.01	0.01
Markers of inflammation/coagulation
APC	0.37	0.01 to 0.01	0.01	< 0.0001
PLR	0.42	− 0.01 to − 0.01	0.01
hs-CRP (mg/dl)	0.10	− 0.01 to 0.01	0.01
Fibrinogen (mg/dl)	0.23	− 0.01 to 0.01	0.01
D-dimer (ng/ml)	0.09	− 0.01 to 6.6	6.98
Markers of tissue damages
hs-cTnI (pg/ml)	0.14	− 0.01 to 0.01	0.01	0.0001
Creatinine (mg/dl)	0.15	− 0.38 to 0.40	0.19
Ferritin (ng/ml)	0.44	− 0.01 to 0.01	0.01
LDH (U/l)	0.47	− 0.01 to 0.01	0.01

The coefficient of determination R², the 95% confidence interval, the standard error and the p values are reported

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