Fig. 8

Gene signature analysis on our COVID-19 patients/low FT3 and COVID-19 patients/normal FT3. a Principal component analysis (PCA) applied to COVID-19 patients with low FT3 values (red circle) and those with normal FT3 values (blue circle) based on 4-gene signature; b unsupervised hierarchical clustered heatmap analysis for the Pearson correlation of absolute mRNA transcript abundance, as determined by NanoString. c Box-plot of log10(norm.counts) of the four genes contigs depending on FT3 serum levels, assessed by NanoString. The gene signature shows a different profile between COVID-19 patients in the presence or in the absence of the Low T3 syndrome. In particular, 3 genes are upregulated and 1 gene is downregulated in COVID-19 patients with low FT3 serum values, compared to patients with normal FT3 serum values. Patients Sand-006 and Sand-011 had an associated hematological malignancy. * means p value ≤ 0.05; ** means p value ≤ 0.005