Fig. 1

Circulatory levels of Alzheimer Disease (AD)-related proteins at baseline and upon glucose level normalization in T2D subjects. Blood sampling was performed at baseline (BL) in both controls (white circles) and T2D (black squares), and at glucose normalization (BM) in T2D subjects. At baseline (BL), blood sugar (BS) was 7.5 ± 0.4 mM (for T2D) and 5.0 ± 0.1 mM (for control, C). Proteomic (Somalogic) analysis of amyloid-related proteins was undertaken for fifteen amyloid-related proteins included in this analysis: Amyloid precursor protein [APP], Amyloid P component [APCS], Noggin, Alpha-synuclein [SNCA], Microtubule-associated protein tau [MAPT], Pappalysin [PAPPA] and Serum amyloid A1 [SAA1], Apolipoprotein A1 [ApoA1], Apolipoprotein B [ApoB], Apolipoprotein E [ApoE], Apolipoprotein E2 [ApoE2], Apolipoprotein E3 [ApoE3], Apolipoprotein E4 [ApoE4], Clusterin [CLU] and complement C3 (C3). Only proteins with changes at baseline between T2D and controls, or changes between BL and BM in T2D. Statistics: T2D vs control at BL: ^p < 0.05, *p < 0.01; T2D BL vs BM: $p < 0.05. RFU, relative fluorescent units