Fig. 4

KEGG pathway analysis of the 13 OAMs. a The number of overlapping pathways among CHB, cirrhosis and HCC. b The 24 altered pathways were divided into 10 categories. c, d Altered signaling pathways in the progression of HBV-associated HCC. Altered pathways are denoted as blue rectangles. HBV-encoded proteins (hepatitis B x, HBx) are marked as red polygons, which stimulate/activate/influence genes adjacent to the HBx proteins. The genes in the OAMs are represented as purple ellipses. ECAD (CDH1), E-cadherin; ERBB2, erb-b2 receptor tyrosine kinase 2; IL-8 (IL8), interleukin 8; CCL-2 (CCL2), C–C motif chemokine 2; TRAIL (TNFSF10), tumor necrosis factor ligand superfamily member 10; TRAIL-R (TNFRSF10, TRAILR), tumor necrosis factor receptor superfamily member 10; Src (SRC), tyrosine-protein kinase Src; α12/13 (GNA12), guanine nucleotide-binding protein subunit alpha-12; αq/11 (GNA11), guanine nucleotide-binding protein subunit alpha-11; SOCS (SOCS3), suppressor of cytokine signaling 3; PTEN, phosphatase and tensin homolog; FAK (PTK2), focal adhesion kinase 1; PI3K (PIK3CA), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; PKB/Akt (AKT1), v-akt murine thymoma viral oncogene homolog 1; PKC, classical protein kinase C; Rac1 (RAC1, Rac-1), Ras-related C3 botulinum toxin substrate 1; Nox, NADPH oxidase; JNK (MAPK8), c-Jun N-terminal kinase, mitogen-activated protein kinase 8; RASSF1 (RASSF1A) Ras association (RalGDS/AF-6) domain family member 1; ERK (MAPK1_3), mitogen-activated protein kinase 1/3; Bcl-2 (BCL2), B-cell CLL/lymphoma 2; Bcl-XL (Bcl2l1), BCL2-like 1; cIAPs (BIRC3), baculoviral IAP repeat containing 3; COX-2 (PTGS2, COX2), prostaglandin-endoperoxide synthase 2; VEGF (VEGFA), vascular endothelial growth factor A; IL-6 (IL6), interleukin 6; MMPs (MMP2), matrix metalloproteinase-2; IFN-α (IFNA), interferon alpha; HLA-E (MHC), major histocompatibility complex, class I, E; MICA, MHC class I polypeptide-related sequence A; CD8 (CD8A), CD8a molecule; CD94 (KLRD1), killer cell lectin-like receptor subfamily D member 1; NKG2A/B (KLRC1), killer cell lectin-like receptor subfamily C, member 1; NKG2D (KLRK1), killer cell lectin-like receptor subfamily K member 1