Fig. 2
From: GRP78 in lung cancer
Role of GRP78 in lung cancer. Complex conditions in the tumor microenvironment lead to the upregulation of GRP78 and its cell surface expression in lung cancer. GRP78 regulates lung cancer tumorigenesis, apoptosis, autophagy, invasion and metastasis, and chemotherapy resistance in a UPR-dependent and UPR-independent manner (see text for more details)