The value of kidney injury molecule 1 in predicting acute kidney injury in adult patients: a systematic review and Bayesian meta-analysis

Geng, Jiwen; Qiu, Yuxuan; Qin, Zheng; Su, Baihai

doi:10.1186/s12967-021-02776-8

Table 1 Characteristics of studies included in the meta-analysis

From: The value of kidney injury molecule 1 in predicting acute kidney injury in adult patients: a systematic review and Bayesian meta-analysis

Study_year	Country	Design	Population settings	Blinding of investigators	Definition of AKI	Sample size	Patients with AKI	Age (y)	Males	Baseline eGRF (ml/min/1.73 m²)	Baseline Scr (mg/dl)
Khreba_2019	Egypt	Prospective cohort study	CPB surgery	NR	KDIGO criteria	45	27	46.26	23 (51.1%)	NR	NR
Wybraniec_2017	Poland	Prospective observational study	Patients with coronary angiography/percutaneous coronary interventions	NR	≥ 50% relative or ≥ 0.3 mg/dl absolute increase of SCr at 48 h after procedure	95	9	65	66 (69.5%)	NR	NR
Sinkala_2016	Zambia	Case–control study	General hospital ward	NR	NR	80	13	35.6	50 (62.5%)	NR	6.90^a
van Wolfswinkel_2016	The Netherlands	Prospective study	Patients with malaria	NR	KDIGO criteria	39	6	45.5^a	33 (84.6%)	NR	1.26^a
Torregrosa_2014	Spain	Prospective study	Patients in ICU	NR	RIFLE criteria	193	35	64.6^a	147 (76.2%)	77.70^a	1.00^a
Tekce_2014	Turkey	Prospective cohort study	Patients with solid tumours	NR	AKIN criteria	22	8	57.3^a	16 (72.7%)	102.91^a	0.92^a
Nickolas_2012	USA	Prospective cohort study	Patients in emergency department	YES	≥ 50% increase in SCr more than 3 days and patients exposed to stimuli	1635	96	64.4	855 (52.3%)	70.5	0.9
Naggar_2012	Egype	Case–control study	Critically ill patients	NR	RIFLE criteria	40	20	51.8^a	16 (40.0%)	83.23^a	0.90^a
Endre_2011	New Zealand; Australia; USA	Prospective observational study	Patients in ICU	YES	≥ 0.3 mg/dl or ≥ 50% increase in plasma creatinine from baseline	528	147	60	318 (60.2%)	NR	NR
Liang_2010	China	Case–control study	CPB surgery	YES	RIFLE criteria	122	30	30a	NR	NR	1.01^a
Ferguson_2010	USA	Cross-sectional study	General hospital ward	NR	≥ 50% increase in SCr	134	92	62.6^a	81 (60.4%)	NR	NR
Liangos_2009	USA	Prospective cohort study	CPB surgery	YES	Increase in serum creatinine by ≥ 50% in the first 72 h following termination of CPB	103	13	68	74 (71.8%)	73	1.1
Han_2009	USA	Prospective cohort study	CPB surgery	YES	Increase in Scr of ≥ 0.3 mg/dl or 2- to threefold from baseline within the first 72 h after surgery	90	36	63.6^a	61 (67.8%)	NR	1.04^a
Vaidya_2008	USA	Cross-sectional study	General hospital ward	NR	RIFLE criteria	204	102	56.9^a	102 (50%)	NR	NR

AKI acute kidney injury, CPB cardiopulmonary bypass, SCr serum creatinine, ICU intensive care unit, eGRF estimated glomerular filtration rate, NR not reported, KIDGO Kidney Disease Improving Global Guidelines, AKIN acute kidney injury network, RIFLE, risk, injury, failure, loss, end-stage renal disease, USA United States of America
^aMean baseline SCr level (mg/dl), eGRF (ml/min/1.73 m²) or age (y, year)

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ISSN: 1479-5876

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