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Table 1 Characteristics of studies included in the meta-analysis

From: The value of kidney injury molecule 1 in predicting acute kidney injury in adult patients: a systematic review and Bayesian meta-analysis

Study_year Country Design Population settings Blinding of investigators Definition of AKI Sample size Patients with AKI Age (y) Males Baseline eGRF (ml/min/1.73 m2) Baseline Scr (mg/dl)
Khreba_2019 Egypt Prospective cohort study CPB surgery NR KDIGO criteria 45 27 46.26 23 (51.1%) NR NR
Wybraniec_2017 Poland Prospective observational study Patients with coronary angiography/percutaneous coronary interventions NR ≥ 50% relative or ≥ 0.3 mg/dl absolute increase of SCr at 48 h after procedure 95 9 65 66 (69.5%) NR NR
Sinkala_2016 Zambia Case–control study General hospital ward NR NR 80 13 35.6 50 (62.5%) NR 6.90a
van Wolfswinkel_2016 The Netherlands Prospective study Patients with malaria NR KDIGO criteria 39 6 45.5a 33 (84.6%) NR 1.26a
Torregrosa_2014 Spain Prospective study Patients in ICU NR RIFLE criteria 193 35 64.6a 147 (76.2%) 77.70a 1.00a
Tekce_2014 Turkey Prospective cohort study Patients with solid tumours NR AKIN criteria 22 8 57.3a 16 (72.7%) 102.91a 0.92a
Nickolas_2012 USA Prospective cohort study Patients in emergency department YES ≥ 50% increase in SCr more than 3 days and patients exposed to stimuli 1635 96 64.4 855 (52.3%) 70.5 0.9
Naggar_2012 Egype Case–control study Critically ill patients NR RIFLE criteria 40 20 51.8a 16 (40.0%) 83.23a 0.90a
Endre_2011 New Zealand;
Australia; USA
Prospective observational study Patients in ICU YES ≥ 0.3 mg/dl or ≥ 50% increase in plasma creatinine from baseline 528 147 60 318 (60.2%) NR NR
Liang_2010 China Case–control study CPB surgery YES RIFLE criteria 122 30 30a NR NR 1.01a
Ferguson_2010 USA Cross-sectional study General hospital ward NR ≥ 50% increase in SCr 134 92 62.6a 81 (60.4%) NR NR
Liangos_2009 USA Prospective cohort study CPB surgery YES Increase in serum creatinine by ≥ 50% in the first 72 h following termination of CPB 103 13 68 74 (71.8%) 73 1.1
Han_2009 USA Prospective cohort study CPB surgery YES Increase in Scr of ≥ 0.3 mg/dl or 2- to threefold from baseline within the first 72 h after surgery 90 36 63.6a 61 (67.8%) NR 1.04a
Vaidya_2008 USA Cross-sectional study General hospital ward NR RIFLE criteria 204 102 56.9a 102 (50%) NR NR
  1. AKI acute kidney injury, CPB cardiopulmonary bypass, SCr serum creatinine, ICU intensive care unit, eGRF estimated glomerular filtration rate, NR not reported, KIDGO Kidney Disease Improving Global Guidelines, AKIN acute kidney injury network, RIFLE, risk, injury, failure, loss, end-stage renal disease, USA United States of America
  2. aMean baseline SCr level (mg/dl), eGRF (ml/min/1.73 m2) or age (y, year)