Fig. 1

Identification and verification of key miRNAs in M2 macrophage-derived exosomes. a Volcano plot of dataset GSE51332. b Heat maps of the expression profiles of seven miRNAs. c Expression of CD206 and CD68 in M0, M1, M2 macrophages. d Biomarkers detection in M1 macrophages compared to M2 macrophages. e Biomarkers detection of M2 macrophages compared to M1 macrophages. f Relative expressions of selected seven miRNAs in M2 macrophages compared to M1 macrophages. g Identification of exosome structure under JEM-2010 HT transmission electron microscope (Scale bar = 50 nm). h The size distributions and numbers of exosomes was analyzed by NTA. i Biomarker detection of M2 macrophage exosomes. j Expression of miR-15a in exosomes derived from macrophages with different differentiation states. k Expression of miR-92a in exosomes derived from macrophages with different differentiation states. Error bars denote standard deviation of triplicates. ***P < 0.001; **P < 0.01; *P < 0.05