Fig. 3
From: Lipoprotein glomerulopathy induced by ApoE Kyoto mutation in ApoE-deficient mice
Renal pathologic lesions in the five groups. Panels a–e show the toluidine blue stain in the five groups. * represent the typical lipoprotein thrombi accumulated in the dilated capillary lumina of glomeruli in AD-ApoE Kyoto and AD-ApoE Sendai group. Panels f–j show ApoE immunofluorescence stain of glomeruli in five groups, positive ApoE staining are existed in AD-ApoE Kyoto, AD-ApoE3 and AD-ApoE Sendai groups. Panels k–o show electron microscopy manifestation of the five groups, osmiophilic granules and various lipid vacuoles accumulated in dilated capillary lumina and mesangial area of glomeruli in AD-ApoE Kyoto and AD-ApoE Sendai group but were absent in other groups