Fig. 5

Combination of dasatinib and tofacitinib with a subtherapeutic dose of anti-hTNF agents ameliorate arthritis pathology. Clinical (a) and histopathological (b) arthritis scores showing the response of Tg197 animals treated with dasatinib 30 mg/Kg alone or in combination with 3 mg/Kg Etanercept (twice weekly) or 1 mg/Kg Adalimumab, Infliximab or Golimumab (twice weekly) (* p-value < 0.05; **p-value; < 0.01***p-value ≤ 0.0001, comparisons made to vehicle). All data are shown as mean ± SEM. Clinical (c) and histopathological (d) arthritis scores showing the response of Tg197 animals treated with 3 mg/Kg Etanercept (thrice weekly) alone, tofacitinib 50 mg/Kg alone or in combination of the two drugs (* p-value < 0.05; ***p-value ≤ 0.0001, comparisons made to vehicle). All data are shown as mean ± SEM