Table 1 List of commercially available skin grafts

Synthetic substitute (acellular)

Integra DRT^®

(acellular dermal analog)

Integra^®

Lifesciences Corp., USA

Full-thickness burn wounds, full-thickness non-thermal treatment, chronic ulcer

Cross-linked matrix made up of bovine type-1 collagen and shark chondroitin-6-sulfate coated with silicone on one side

[13,14,15,16]

Alloderm^®

(human acellular dermal matrix)

LifeCell Inc., Branchburg, NJ, USA

Deep partial and full- thickness wounds

Freeze dried human acellular dermis

[17, 18]

Biobrane^®

(epidermis and dermis analog)

Mylan Bertek

Pharmaceuticals, USA

Commonly used in pediatric burns and donor sites of split thickness skin

Silicone bonded to woven nylon containing type I collagen peptides

[16, 19]

OASIS wound matrix

Cook Biotech Inc., West Lafayette, IN, USA

Chronic leg ulcer, acute, chronic and burn wounds

Porcine small-intestine submucosa

[16, 20]

Hyalomatrix^® tissue reconstruction matrix

Fidia Advanced Biopolymers, Abano Terme, Italy

Pressure ulcers, diabetic foot ulcers, and deep second-degree burns

Derivatized hyaluronic acid

[21]

Matriderm^®

MedSkin Solution Dr. Suwelack AG, Billerbeck, Germany

Full thickness burns and reconstuctive surgery

Bovine collagen and elastin

[21, 22]

Synthetic substitute (allogenic cells)

TransCyte^® (allogenic cellular allogenic skin sub)

Advanced BioHealing, Inc., USA

Partial-thickness burn wounds and donor site treatment

Neonatal allogenic fibroblast cultured on collagen-coated nylon mesh

[16, 23]

Natural skin substitute (allogenic cells)

Dermagraft^®

(allogenic dermal sub)

Advanced BioHealing, Inc., USA

Chronic wounds and diabetic foot ulcers

Biodegradable polyglactin mesh combined with neonatal foreskin fibroblast

[24, 25]

Apligraf^®

(allogenic—both living epidermis and dermis)

Organogenesis Inc., USA

Diabetic foot ulcers

Bovine type I collagen matrix combined with allogenic neonatal foreskin fibroblast and keratinocytes

[26]

Orcel^® (allogenic—both living epidermis and dermis)

Ortec International Inc., New York, NY, USA

Treat donor sites in burns, surgical wounds, partial thickness wounds and recessive dystrophic epidermolysis bullosa

Bovine collagen type I matrix seeded with fibroblast and keratinocytes derived from neonatal foreskin

[27, 28]

Natural skin substitute (autologous cells)

Epicel^®

Genzyme Biosurgery, USA

Full thickness burns

Autologous keratinocytes sheets attached to petrolatum gauze support

[29, 30]

Epidex

Modex Therapeutiques, Lausanna, Switzerland

Improvement of relatively small chronic leg ulcers

Cultured keratinocytes sheets derived from outer root sheath of anagen hair follicles

[28, 31]

Laserskin^®

Fidia Advanced Biopolymers Srl, Italy

Foot ulcers

Autologous keratinocytes and fibroblasts, grown on microperforated hyaluronic acid membranes

[6, 16]