Table 7 Factorial analysis SNP rs1044250 and weight management on clinical characteristic changes
| Â | Weight loss | Weight gain | p | ||||||
|---|---|---|---|---|---|---|---|---|---|
CC (n = 709) | CT (n = 146) | TT (n = 11) | CC (n = 132) | CT (n = 32) | TT (n = 3) | rs1044250 | ΔWeight | rs1044250 *ΔWeight | |
ΔWeight (kg) | − 2.23 ± 2.81 | − 2.27 ± 2.68 | − 2.25 ± 1.35 | 0.94 ± 2.24 | 0.53 ± 0.81 | 0.67 ± 1.15 |  |  |  |
ΔBMI (kg/m2) | − 0.61 ± 0.94 | − 0.61 ± 0.97 | − 0.62 ± 0.51 | 0.61 ± 1.16 | 0.36 ± 0.38 | 0.55 ± 0.54 |  |  |  |
ΔWC (cm) | − 4.46 ± 3.11 | − 4.26 ± 2.76 | − 5.45 ± 2.05 | 1.10 ± 2.33 | 0.20 ± 2.11 | 0.67 ± 2.75 |  |  |  |
ΔSBP (mmHg) | − 6.48 ± 13.12 | − 5.79 ± 10.81 | − 4.55 ± 8.55 | 0.04 ± 8.77 | − 6.12 ± 13.51c | 0.33 ± 5.86 | 0.113 | 0.191 | 0.038 |
ΔDBP (mmHg) | − 5.06 ± 6.70 | − 4.51 ± 6.40 | − 5.97 ± 7.13 | − 0.78 ± 4.14 | − 3.51 ± 6.99 c | 0.56 ± 0.84 | 0.285 | 0.007 | 0.049 |
ΔTG (mmol/L) | − 0.69 ± 1.69 | − 0.58 ± 1.39 | − 1.33 ± 1.91 | − 0.14 ± 1.64 | − 0.48 ± 1.33 | 0.79 ± 0.31 |  |  |  |
ΔTC (mmol/L) | − 0.30 ± 1.28 | − 0.21 ± 1.36 | − 0.80 ± 1.74 | 0.07 ± 1.22 | − 0.17 ± 0.89 | 0.59 ± 1.97 |  |  |  |
ΔHDL-c (mmol/L) | − 0.25 ± 0.64 | − 0.31 ± 0.59 | − 1.07 ± 0.97a, b | − 0.22 ± 0.53 | − 0.19 ± 0.67 | 0.41 ± 0.83 | 0.889 |  < 0.001 | 0.002 |
ΔFPG (mmol/L) | − 0.04 ± 2.32 | − 0.24 ± 2.47 | − 0.12 ± 1.98 | 0.16 ± 1.96 | − 0.21 ± 2.16 | 0.34 ± 0.75 |  |  |  |