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Table 7 Factorial analysis SNP rs1044250 and weight management on clinical characteristic changes

From: Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome

  Weight loss Weight gain p
CC (n = 709) CT (n = 146) TT (n = 11) CC (n = 132) CT (n = 32) TT (n = 3) rs1044250 ΔWeight rs1044250 *ΔWeight
ΔWeight (kg) − 2.23 ± 2.81 − 2.27 ± 2.68 − 2.25 ± 1.35 0.94 ± 2.24 0.53 ± 0.81 0.67 ± 1.15    
ΔBMI (kg/m2) − 0.61 ± 0.94 − 0.61 ± 0.97 − 0.62 ± 0.51 0.61 ± 1.16 0.36 ± 0.38 0.55 ± 0.54    
ΔWC (cm) − 4.46 ± 3.11 − 4.26 ± 2.76 − 5.45 ± 2.05 1.10 ± 2.33 0.20 ± 2.11 0.67 ± 2.75    
ΔSBP (mmHg) − 6.48 ± 13.12 − 5.79 ± 10.81 − 4.55 ± 8.55 0.04 ± 8.77 − 6.12 ± 13.51c 0.33 ± 5.86 0.113 0.191 0.038
ΔDBP (mmHg) − 5.06 ± 6.70 − 4.51 ± 6.40 − 5.97 ± 7.13 − 0.78 ± 4.14 − 3.51 ± 6.99 c 0.56 ± 0.84 0.285 0.007 0.049
ΔTG (mmol/L) − 0.69 ± 1.69 − 0.58 ± 1.39 − 1.33 ± 1.91 − 0.14 ± 1.64 − 0.48 ± 1.33 0.79 ± 0.31    
ΔTC (mmol/L) − 0.30 ± 1.28 − 0.21 ± 1.36 − 0.80 ± 1.74 0.07 ± 1.22 − 0.17 ± 0.89 0.59 ± 1.97    
ΔHDL-c (mmol/L) − 0.25 ± 0.64 − 0.31 ± 0.59 − 1.07 ± 0.97a, b − 0.22 ± 0.53 − 0.19 ± 0.67 0.41 ± 0.83 0.889  < 0.001 0.002
ΔFPG (mmol/L) − 0.04 ± 2.32 − 0.24 ± 2.47 − 0.12 ± 1.98 0.16 ± 1.96 − 0.21 ± 2.16 0.34 ± 0.75    
  1. Continuous variables are recorded by \(\stackrel{-}{x}\pm S\)
  2. Δ: follow-up values minus baseline values; BMI: body mass index; WC: waist circumference; SBP: systolic blood pressure; DBP: diastolic blood pressure; TG: triglyceride; TC: total cholesterol; HDL-c: high-density lipoprotein-cholesterol; FPG: fasting plasma glucose
  3. aStatistically significant compared with CC genotype in the Weight loss group; bStatistically significant compared with CT genotype in the Weight loss group; cStatistically significant compared with CC genotype in the Weight gain group