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Table 5 Multivariate Cox PH models testing the associations of age, stage, MacReg, and IFNγRes with melanoma OS in high TMB and low TMB subpopulations

From: Tumor immunogenomic signatures improve a prognostic model of melanoma survival

Model Covariate TMB High (N = 220) TMB Low (N = 58)
HR (95% CI) Covariate P (Wald) Model P (log-rank) HR (95% CI) Covariate P (Wald) Model P (log-rank)
Age + Stage + MacReg Age 1.02 (1.01–1.04) 2.17E−03 9.70E−07 1.02 (0.99–1.05) 0.23 0.07
Stage 1.89 (1.20–2.97) 5.74E−03 1.31 (0.66–2.61) 0.44
MacReg 0.64 (0.49–0.84) 1.19E−03 0.65 (0.44–0.97) 3.26E−02
Age + Stage + IFNγRes Age 1.03 (1.01–1.04) 6.50E−04 4.40E−08 1.02 (0.99–1.05) 0.21 0.32
Stage 2.11 (1.34–3.33) 1.36E−03 1.22 (0.61–2.45) 0.57
IFNγRes 0.61 (0.48–0.77) 4.39E−05 0.83 (0.58–1.19) 0.31
Age + Stage + MacReg + IFNγRes Age 1.02 (1.01–1.04) 1.42E−03 6.60E-08 1.02 (0.99–1.05) 0.20 0.11
Stage 2.05 (1.30–3.25) 2.06E-03 1.42 (0.69–2.90) 0.34
MacReg 0.83 (0.59–1.16) 0.27 0.56 (0.32–0.96) 3.43E-02
IFNγRes 0.67 (0.50–0.90) 7.75E-03 1.22 (0.75–1.97) 0.42
  1. Hazard ratios and 95% confidence intervals (HR 95% CI) and p-values for each variable in each model are reported. Overall model goodness-of-fit as determined by log-rank tests are reported