Fig. 1

Kaplan–Meier survival curves showing the association of IFNγRes and MacReg signatures in high TMB and low TMB cohorts with melanoma OS. The analysis is performed in high TMB (> 125 mutations) (a) or low TMB (≤ 125 mutations) (b). Panel A shows high IFNγRes and high MacReg vs low IFNγRes and low MacReg in patients with high TMB, panel B shows high IFNγRes and high MacReg vs low IFNγRes and low MacReg in patients with low TMB and c shows low IFNγRes and low MacReg in patients with high TMB vs. patients with low TMB. The vertical dotted lines represent median survival times. All p-values are from log-rank tests