Fig. 4

Hepatic inflammation and activation of stellate cells was induced in the NASH-STZ hamster and was prevented or reversed by insulin treatment. Representative sections of liver from the NASH-STZ group (a, c, e, g, i) and the NASH-STZ-HI group (b, d, f, h, j) displaying positive staining of markers CD68 (a, b), CD11b (c, d), CD45 (e, f), αSMA (g, h), Picro Sirius Red (i, j). Smallest insert in upper right corner of a: CD68 and Oil Red O double stain (x40 magnification). Inserts in a, c, e, g and i: x10 magnifications of positively stained cells/fibres