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Table 3 The results of GSEA for HELQ and EGR3 with significantly enriched pathways

From: HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia

  Pathway Enrichment Score NES P value FDR adjusted p value Q values
HELQ expression associated pathways Kras signaling − 0.435668418 − 2.1532 1.00E−10 5.00E−09 3.05E−09
Hedgehog signaling − 0.42542167 − 1.6012 0.00905 0.0266321 0.01626
coagulation − 0.40041732 − 1.9035 1.78E−06 1.78E−05 1.09E−05
Myogenesis − 0.366088795 − 1.8159 3.62E−06 2.64E−05 1.61E−05
Epithelial mesenchymal transition − 0.365397776 − 1.8159 3.69E−06 2.64E−05 1.61E−05
Bile acid metabolism − 0.340839788 − 1.5737 0.00346 0.0123508 0.00754
Estrogen response late − 0.335392317 − 1.6646 7.44E−05 0.0004131 0.00025
Inflammatory response − 0.332882791 − 1.6521 0.0001 0.000507 0.00031
Spermatogenesis − 0.312304664 − 1.4807 0.00614 0.0191922 0.01172
Estrogen response early − 0.307378963 − 1.5247 0.00124 0.0051754 0.00316
Xenobiotic metabolism − 0.304376309 − 1.5098 0.00158 0.0060767 0.00371
DNA repair 0.240957608 1.47711 0.00535 0.0178322 0.01089
MYC targets 0.255275512 1.66642 7.34E−05 0.0004131 0.00025
G2M checkpoint 0.301740945 1.98069 1.82E−07 2.28E−06 1.39E−06
E2F targets 0.304239585 1.99709 1.16E−07 1.93E−06 1.18E−06
Mitotic spindle 0.30860828 1.97486 4.61E−08 1.15E−06 7.04E−07
Protein secretion 0.32775742 1.88719 0.00013 0.0005808 0.00035
EGR3 expression associated pathways Interferon alpha response − 0.498828541 − 2.3019 7.24E−09 3.62E−07 1.45E−07
Cholesterol homeostasis − 0.433630867 − 1.8937 8.29E−05 0.0003453 0.00014
Reactive oxigen species pathway − 0.410797211 − 1.6669 0.00434 0.0120436 0.00482
Coagulation − 0.381436147 − 1.8811 8.40E−06 5.59E−05 2.24E−05
Myogenesis − 0.35817246 − 1.8869 3.24E−06 3.24E−05 1.30E−05
Interferon gamma response − 0.353929759 − 1.8643 1.82E−06 2.27E−05 9.09E−06
IL6-JAK-STAT3 signaling − 0.345542037 − 1.5649 0.00978 0.0232876 0.00932
Kras signaling − 0.329603523 − 1.732 8.04E−05 0.0003453 0.00014
epithelial mesenchymal transition − 0.32757194 − 1.7247 4.34E−05 0.0002168 8.67E−05
Estrogen response late − 0.321965048 − 1.6931 0.00013 0.0004868 0.00019
Inflammatory response − 0.306318547 − 1.6109 0.00055 0.0019486 0.00078
Complement − 0.286012557 − 1.5067 0.00293 0.0086057 0.00344
Apoptosis − 0.278729142 − 1.4182 0.01129 0.0243914 0.00976
Estrogen response early − 0.272180964 − 1.4339 0.00861 0.0215358 0.00861
Glycolysis − 0.268495638 − 1.4144 0.01088 0.0243914 0.00976
Adipogenesis − 0.26708006 − 1.4058 0.00807 0.0212352 0.00849
Hypoxia − 0.264798339 − 1.3925 0.01171 0.0243914 0.00976
Allograft rejection − 0.260668803 − 1.3732 0.01705 0.0340906 0.01364
PI3K-Akt-mTOR signaling 0.312772587 1.4756 0.01953 0.0375598 0.01502
DNA repair 0.326826349 1.62277 0.00084 0.0027889 0.00112
Mitotic spindle 0.339594124 1.78072 3.16E−05 0.0001753 7.01E−05
G2M checkpoint 0.357870462 1.86809 4.20E−06 3.50E−05 1.40E−05
E2F targets 0.399460879 2.08519 2.71E−08 4.51E−07 1.80E−07
MYC targets v1 0.401746954 2.09159 1.97E−08 4.51E−07 1.80E−07
MYC targets v2 0.428081704 1.80452 0.00173 0.0054071 0.00216
Protein secretion 0.440075051 2.06176 8.94E−06 5.59E−05 2.24E−05