HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia

Guo, Chao; Gao, Ya-yue; Ju, Qian-qian; Zhang, Chun-xia; Gong, Ming; Li, Zhen-ling

doi:10.1186/s12967-021-02708-6

Journal of Translational Medicine

Table 3 The results of GSEA for HELQ and EGR3 with significantly enriched pathways

From: HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia

	Pathway	Enrichment Score	NES	P value	FDR adjusted p value	Q values
HELQ expression associated pathways	Kras signaling	− 0.435668418	− 2.1532	1.00E−10	5.00E−09	3.05E−09
	Hedgehog signaling	− 0.42542167	− 1.6012	0.00905	0.0266321	0.01626
	coagulation	− 0.40041732	− 1.9035	1.78E−06	1.78E−05	1.09E−05
	Myogenesis	− 0.366088795	− 1.8159	3.62E−06	2.64E−05	1.61E−05
	Epithelial mesenchymal transition	− 0.365397776	− 1.8159	3.69E−06	2.64E−05	1.61E−05
	Bile acid metabolism	− 0.340839788	− 1.5737	0.00346	0.0123508	0.00754
	Estrogen response late	− 0.335392317	− 1.6646	7.44E−05	0.0004131	0.00025
	Inflammatory response	− 0.332882791	− 1.6521	0.0001	0.000507	0.00031
	Spermatogenesis	− 0.312304664	− 1.4807	0.00614	0.0191922	0.01172
	Estrogen response early	− 0.307378963	− 1.5247	0.00124	0.0051754	0.00316
	Xenobiotic metabolism	− 0.304376309	− 1.5098	0.00158	0.0060767	0.00371
	DNA repair	0.240957608	1.47711	0.00535	0.0178322	0.01089
	MYC targets	0.255275512	1.66642	7.34E−05	0.0004131	0.00025
	G2M checkpoint	0.301740945	1.98069	1.82E−07	2.28E−06	1.39E−06
	E2F targets	0.304239585	1.99709	1.16E−07	1.93E−06	1.18E−06
	Mitotic spindle	0.30860828	1.97486	4.61E−08	1.15E−06	7.04E−07
	Protein secretion	0.32775742	1.88719	0.00013	0.0005808	0.00035
EGR3 expression associated pathways	Interferon alpha response	− 0.498828541	− 2.3019	7.24E−09	3.62E−07	1.45E−07
	Cholesterol homeostasis	− 0.433630867	− 1.8937	8.29E−05	0.0003453	0.00014
	Reactive oxigen species pathway	− 0.410797211	− 1.6669	0.00434	0.0120436	0.00482
	Coagulation	− 0.381436147	− 1.8811	8.40E−06	5.59E−05	2.24E−05
	Myogenesis	− 0.35817246	− 1.8869	3.24E−06	3.24E−05	1.30E−05
	Interferon gamma response	− 0.353929759	− 1.8643	1.82E−06	2.27E−05	9.09E−06
	IL6-JAK-STAT3 signaling	− 0.345542037	− 1.5649	0.00978	0.0232876	0.00932
	Kras signaling	− 0.329603523	− 1.732	8.04E−05	0.0003453	0.00014
	epithelial mesenchymal transition	− 0.32757194	− 1.7247	4.34E−05	0.0002168	8.67E−05
	Estrogen response late	− 0.321965048	− 1.6931	0.00013	0.0004868	0.00019
	Inflammatory response	− 0.306318547	− 1.6109	0.00055	0.0019486	0.00078
	Complement	− 0.286012557	− 1.5067	0.00293	0.0086057	0.00344
	Apoptosis	− 0.278729142	− 1.4182	0.01129	0.0243914	0.00976
	Estrogen response early	− 0.272180964	− 1.4339	0.00861	0.0215358	0.00861
	Glycolysis	− 0.268495638	− 1.4144	0.01088	0.0243914	0.00976
	Adipogenesis	− 0.26708006	− 1.4058	0.00807	0.0212352	0.00849
	Hypoxia	− 0.264798339	− 1.3925	0.01171	0.0243914	0.00976
	Allograft rejection	− 0.260668803	− 1.3732	0.01705	0.0340906	0.01364
	PI3K-Akt-mTOR signaling	0.312772587	1.4756	0.01953	0.0375598	0.01502
	DNA repair	0.326826349	1.62277	0.00084	0.0027889	0.00112
	Mitotic spindle	0.339594124	1.78072	3.16E−05	0.0001753	7.01E−05
	G2M checkpoint	0.357870462	1.86809	4.20E−06	3.50E−05	1.40E−05
	E2F targets	0.399460879	2.08519	2.71E−08	4.51E−07	1.80E−07
	MYC targets v1	0.401746954	2.09159	1.97E−08	4.51E−07	1.80E−07
	MYC targets v2	0.428081704	1.80452	0.00173	0.0054071	0.00216
	Protein secretion	0.440075051	2.06176	8.94E−06	5.59E−05	2.24E−05

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