Table 2 The comparison of hub genes (HELQ/EGR3/ZNF667/SOWAHC) expression indicated significant difference between M-CLL and U-CLL using unpaired t-test. Since the HELQ expression was not included in the platform of GSE9992, the p-value was not calculated
| Â | GSE38611 (76M-CLL vs 60 U-CLL) | GSE40570 (96M-CLL vs 63 U-CLL) | GSE51529 (131M-CLL vs 85 U-CLL) | GSE69034 (86M-CLL vs 58 U-CLL) | GSE9992 (24M-CLL vs 36 U-CLL) | GSE50006 (188 CLL vs 32 healthy donors) | GSE32018 (17 CLL, 23 FL, 22 DLBCL, 24 MCL, 15 MALT-MZL, 13 NMZL,13 lymphoid tissues |
|---|---|---|---|---|---|---|---|
p value (t test) | p value (t test) | p value (t test) | p value (t test) | p value (t test) | p value (t test) | p value (one-way ANOVA test) | |
HELQ |  < 0.0001 | 0.0004 |  < 0.0001 | 0.748 | NA |  < 0.0001 | 0.0236 |
EGR3 | 0.0003 |  < 0.0001 |  < 0.0001 |  < 0.0001 | 0.0015 | 0.1509 | 0.0493 |
ZNF667 |  < 0.0001 |  < 0.0001 |  < 0.0001 |  < 0.0001 |  < 0.0001 | 0.0034 | 0.0003 |
SOWAHC |  < 0.0001 |  < 0.0001 |  < 0.0001 |  < 0.0001 |  < 0.0001 | 0.9806 | 0.0729 |