Fig. 2

Plasma levels of thyroxine-binding globulin (TBG) and transthyretin in healthy controls and major depressive disorder (MDD) patients treated with either selective serotonin reuptake inhibitors (SSRIs) or mirtazapine. a Comparison between healthy individuals and patients with MDD. Transthyretin was higher in controls than that in MDD patients. b Plasma protein levels in MDD patients treated with SSRIs. TBG levels were increased in responders after SSRIs treatment. However, the difference did not reach statistical significances. c Plasma protein levels in MDD patients treated with mirtazapine. TBG level was increased after mirtazapine treatment. Transthyretin levels tended to be lower in responders. However, this difference did not reach the statistical significance. NR, nonresponder; R, responder