Fig. 7

Correlation between NFAT5 and moderately sulfated heparan sulfate (AO4B08). a Linear regression graph showing the correlation between NFAT5 and AO4B08. NFAT5 expression in the dermis of healthy controls showed a significant positive correlation during LSD (r = 0.76, p = 0.004) with AO4B08. b, c Low expression of dermis NFAT5 in cytoplasm of endothelium (green staining in B) was accompanied by low expression of moderately sulfated heparan sulfate (AO4B08) (blue staining in C) in the dermis. d, e High expression of dermis NFAT5 in both endothelium and in nuclei and cytoplasm of perivascular leukocytes (green staining in D) was accompanied by a high content of moderately sulfated heparan sulfate in the dermis (blue staining in E). * marks a significant correlation. HC, healthy controls. LSD, low sodium diet. HSD, high sodium diet. NFAT5, nuclear factor of activated T-cells 5. n = 12. Data are presented as individual data. Data were tested with Spearman’s correlation coefficient