Transcriptomic analysis identifies organ-specific metastasis genes and pathways across different primary sites

Table 3 KEGG pathways enriched for brain metastasis specific genes

DEG	KEGG pathway	FDR^a	%Genes^b (%)	#Genes^c
Up-regulated	Neuroactive ligand-receptor interaction	< 0.001	12	42
	Cytokine-cytokine receptor interaction	< 0.001	11	32
	PI3K-Akt signaling pathway	0.007	9	31
	JAK-STAT signaling pathway	0.017	10	17
	Signaling pathways regulating pluripotency of stem cells	0.025	10	15
	RIG-I-like receptor signaling pathway	0.043	13	9
Down-regulated	Autophagy	0.001	18	24
	Tight junction	0.003	13	23
	Dopaminergic synapse	0.006	14	19
	AMPK signaling pathway	0.007	15	18
	Endocytosis	0.010	11	28
	Wnt signaling pathway	0.018	13	20
	Inositol phosphate metabolism	0.019	16	12
	FoxO signaling pathway	0.023	13	17
	Lysosome	0.034	13	16
	Neurotrophin signaling pathway	0.039	13	15

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