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Table 3 KEGG pathways enriched for brain metastasis specific genes

From: Transcriptomic analysis identifies organ-specific metastasis genes and pathways across different primary sites

DEG KEGG pathway FDRa %Genesb (%) #Genesc
Up-regulated Neuroactive ligand-receptor interaction < 0.001 12 42
Cytokine-cytokine receptor interaction < 0.001 11 32
PI3K-Akt signaling pathway 0.007 9 31
JAK-STAT signaling pathway 0.017 10 17
Signaling pathways regulating pluripotency of stem cells 0.025 10 15
RIG-I-like receptor signaling pathway 0.043 13 9
Down-regulated Autophagy 0.001 18 24
Tight junction 0.003 13 23
Dopaminergic synapse 0.006 14 19
AMPK signaling pathway 0.007 15 18
Endocytosis 0.010 11 28
Wnt signaling pathway 0.018 13 20
Inositol phosphate metabolism 0.019 16 12
FoxO signaling pathway 0.023 13 17
Lysosome 0.034 13 16
Neurotrophin signaling pathway 0.039 13 15
  1. aThe p-values corrected with Benjamini–Hochberg
  2. bThe percentage of associated genes in each signaling pathway
  3. cThe number of associated genes in each signaling pathway