Fig. 6

Verification of the 8 specifically expressed hub genes by 4 datasets of the GEO database. a Verification by three GPL96 datasets: GSE55584, GSE55457 and GSE55235. Compared with OA samples, all hub genes are upregulated in RA samples with significance. b Verification by the GPL11154 GSE89408 dataset. ***: p < 0.001, **: p < 0.01, *: p < 0.05, ns: no significant difference. Compared with OA samples, all hub genes are upregulated in RA samples with significance. Compared with established RA samples, GZMA, PRC1, and TTK were upregulated in early RA samples, while others have no significance