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Table 1 Drug screens using organoids

From: Patient-derived organoid (PDO) platforms to facilitate clinical decision making

Cancer Paper Drugs used
Breast cancer [28] Afatinib AZD8055 everolimus GDC-0068 gefitinib pictilisib
Clear cell renal cancer [46] Cabozantinib foretinib levantinib + everolimus sunitinib SU11274 tensirolimus
Colorectal cancer [29] ABT-263 AICAR AKT inhibitor VIII AMG-706 axitinib AZ960 AZD-2281 AZD6482 AZD8055 AZD8931 BI-2536 BIBW2992 BIRB-0796 BMN-673 BMS-345541 BMS-536924 BMS-708163 bortezomib BX-795 BYL719 camptothecin CEP-701 cetuximab CHIR-99021 cisplatin dabrafenib dasatanib docetaxel EHT-1864 embelin FK866 fulvestrant GDC-0449 GDC0941 gefitinib gemcitibine GSK269962A GW-441756 INCB-18424 irinotecan-trihydrochloride JNJ-26854165 JNK-inhibitor-VIII JQ1 KU-55933 lenalidomide LY317615 mirin MK-2206 MLN8237 nilotinib NU-7441 nutlin-3a NVP-BEZ235 obatoclax-mesylate OSI-906 oxaliplatin PAC-1 paclitaxel PD-0332991 PD-173074 PF-02341066 PF-4708671 PF477736 PF-562271 PLX4720 RO-3306SB-216763 SB-505124 SCH772984 SGC0946 SL-0101-1 sorafenib temozolomide trametanib UNC0642 vorinostat XAV-939 YK-4-279 ZM-447439 17-AAG 5-fluorouracil (5Z)-7-oxozeaenol 681640
Colorectal cancer [47] Afatinib AKT inhibitor VIII doxorubicin MEK1/2 inhibitor III nutlin-3a 5-fluorouracil
7-Ethyl-10-hydroxycamptothecin (SN-38)
Liver cancer [6] AZD8931a axitinib BIRB-0796 BIRB-1532 CH5424802 cisplatin dabrafenib dasataniba deltarasin doxorubicin EMD-1214063 gemcitibinea GSK126 KU-55933 lapatinib LGK974 LY2109761 MK-2206 nutlin-3a olaparib OSI-027 PD-0332991 PD-173074 SCH772984a sorafenib taselisiba trametinib vorinostat 5-fluorouracil
Prostate cancer [27] BKM-120 enzalutamide everolimus
Ovarian cancer [33] Azacytidine AZD2014 AZD5363 belinostat BKM120 carboplatin cyclopamine DAPT dasatinib decitabine doxorubicin ICG-001 MK-5108 NSC23766 olaparib paclitaxel temsirolimus
  1. aDifferential sensitivities were observed