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Table 2 DNA integrity: distribution of peaks 1 and 2 (A: MagNA Pure 24 System, B: IDEAL, C: LabTurbo 24 AB; D: Chemagic 360D)

From: Qualitative and quantitative comparison of cell-free DNA and cell-free fetal DNA isolation by four (semi-)automated extraction methods: impact in two clinical applications: chimerism quantification and noninvasive prenatal diagnosis

Isolation method A B C D
75–239 bp
 Mean 90% 79% 73% 71%
 SD 9% 7% 9% 8%
 CV 10% 9% 13% 12%
 Min–Max 79–100% 68–85% 61–84% 62–84%
 P 0.0789    
 p B–C–D   0.32
p240–369 bp
 Mean 5% 15% 15% 15%
 SD 5% 3% 3% 3%
 CV 99% 18% 19% 18%
 Min–Max 0–10% 11–17% 10–17% 11–18%
 P < 0.005
 p B–C–D   0.865
370–579 bp
 Mean 1% 3% 6% 7%
 SD 2% 3% 2% 3%
 CV 148% 114% 40% 47%
 Min–Max 0–5% 1–8% 3–9% 2–10%
 P 0.028
 p B–C–D   0.122
580–1649 bp
 Mean 3% 4% 6% 7%
 SD 3% 2% 4% 3%
 CV 83% 54% 68% 41%
 Min–Max 0–7% 2–7% 2–13% 4–10%
 P 0.203
 p B–C–D   0.314