Table 1 Proteins identified as being altered in COVID-19 disease categorized according to biological processes: vessel damage (16 proteins), platelet degranulation (11 proteins), coagulation cascade (24 proteins) and acute phase response (9 proteins) in PCOS and control women
From: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome
Target full name | Target | UniProt | Entrez gene ID | Entrez gene symbol | T-test PCOS vs control |
|---|---|---|---|---|---|
Vessel damage | |||||
 Angiotensinogen | Angiotensinogen | P01019 | 183 | AGT | 0.0240 |
 Angiopoietin-1 | Angiopoietin-1 | Q15389 | 284 | ANGPT1 | 0.0760 |
 Angiogenin | Angiogenin | P03950 | 283 | ANG | 0.2540 |
 EGF-containing fibulin-like extracellular matrix protein 1 | FBLN3 | Q12805 | 2202 | EFEMP1 | 0.4220 |
 Gelsolin | Gelsolin | P06396 | 2934 | GSN | 0.0002 |
 Hemopexin | Hemopexin | P02790 | 3263 | HPX | 0.4390 |
 Inter-alpha-trypsin inhibitor heavy chain H4 | ITI heavy chain H4 | Q14624 | 3700 | ITIH4 | 0.5360 |
 Lumican | Lumican | P51884 | 4060 | LUM | 0.3790 |
 Nidogen-1 | Nidogen | P14543 | 4811 | NID1 | 0.9600 |
 Neuropilin-1 | NRP1 | O14786 | 8829 | NRP1 | 0.0090 |
 Periostin | Periostin | Q15063 | 10631 | POSTN | 0.0490 |
 Ras-related C3 botulinum toxin substrate 1 | RAC1 | P63000 | 5879 | RAC1 | 0.5850 |
 Kallistatin | Kallistatin | P29622 | 5267 | SERPINA4 | 0.0006 |
 Pigment epithelium-derived factor | PEDF | P36955 | 5176 | SERPINF1 | 0.00003 |
 Transforming growth factor-beta-induced protein ig-h3 | BGH3 | Q15582 | 7045 | TGFBI | 0.9890 |
 Tenascin | Tenascin | P24821 | 3371 | TNC | 0.0020 |
 Vitronectin | Vitronectin | P04004 | 7448 | VTN | 0.3930 |
Platelet degranulation | |||||
 Alpha-2-macroglobulin | a2-Macroglobulin | P01023 | 2 | A2M | 0.2660 |
 Clusterin | Clusterin | P10909 | 1191 | CLU | 0.6900 |
 Fibronectin | Fibronectin | P02751 | 2335 | FN1 | 0.0098 |
 Platelet glycoprotein Ib alpha chain | GP1BA | P07359 | 2811 | GP1BA | 0.1560 |
 Histidine-rich glycoprotein | HRG | P04196 | 3273 | HRG | 0.5890 |
 Integrin alpha-IIb: beta-3 complex | gpIIbIIIa | P08514 P05106 | 3674 3690 | ITGA2B ITGB3 | 0.8370 |
 Neutrophil-activating peptide 2 | NAP-2 | P02775 | 5473 | PPBP | 0.2740 |
 Plasma serine protease inhibitor | PCI | P05154 | 5104 | SERPINA5 | 0.0380 |
 Corticosteroid-binding globulin | CBG | P08185 | 866 | SERPINA6 | 0.1790 |
 Thyroxine-binding globulin | Thyroxine-Binding Globulin | P05543 | 6906 | SERPINA7 | 0.5730 |
 Transgelin-2 | Transgelin-2 | P37802 | 8407 | TAGLN2 | 0.8690 |
 von Willebrand factor | vWF | P04275 | 7450 | VWF | 0.0770 |
Coagulation cascade | |||||
 Carboxypeptidase B2 | TAFI | Q96IY4 | 1361 | CPB2 | 0.0170 |
 Prothrombin | Prothrombin | P00734 | 2147 | F2 | 0.0920 |
 Coagulation Factor V | Coagulation Factor V | P12259 | 2153 | F5 | 0.3020 |
 Coagulation factor VII | Coagulation Factor VII | P08709 | 2155 | F7 | 0.2520 |
 Coagulation factor IX | Coagulation Factor IX | P00740 | 2158 | F9 |  < 0.00001 |
 Coagulation factor Xa | Coagulation Factor Xa | P00742 | 2159 | F10 | 0.1620 |
 Coagulation Factor XI | Coagulation Factor XI | P03951 | 2160 | F11 | 0.5190 |
 Fibrinogen | Fibrinogen | P02671 P02675 P02679 | 2243 2244 2266 | FGA FGB FGG | 0.0126 |
 D-dimer | D-dimer | P02671 P02675 P02679 | 2243 2244 2266 | FGA FGB FGG | 0.00002 |
 Fibrinogen gamma chain | Fibrinogen g-chain dimer | P02679 | 2266 | FGG | 0.00002 |
 Hepatocyte growth factor activator | HGFA | Q04756 | 3083 | HGFAC | 0.0830 |
 Plasma kallikrein | Prekallikrein | P03952 | 3818 | KLKB1 | 0.0015 |
 Kininogen-1 | Kininogen, HMW | P01042 | 3827 | KNG1 | 0.7970 |
 Plasminogen | Plasminogen | P00747 | 5340 | PLG | 0.6740 |
 Vitamin K-dependent protein S | Protein S | P07225 | 5627 | PROS1 | 0.00003 |
 Vitamin K-dependent protein C | Protein C | P04070 | 5624 | PROC | 0.5110 |
 Alpha-1-antitrypsin | a1-Antitrypsin | P01009 | 5265 | SERPINA1 | 0.1500 |
 Protein Z-dependent protease inhibitor | protein Z inhibitor | Q9UK55 | 51156 | SERPINA10 | 0.1720 |
 Antithrombin-III | Antithrombin III | P01008 | 462 | SERPINC1 | 0.0003 |
 Heparin cofactor 2 | Heparin cofactor II | P05546 | 3053 | SERPIND1 | 0.00003 |
 Plasminogen activator inhibitor 1 | PAI-1 | P05121 | 5054 | SERPINE1 | 0.1680 |
 Alpha-2-antiplasmin | a2-Antiplasmin | P08697 | 5345 | SERPINF2 |  |
Acute phase response | |||||
 Serum albumin | Albumin | P02768 | 213 | ALB | 0.0660 |
 Macrophage mannose receptor 1 | Macrophage mannose receptor | P22897 | 4360 | MRC1 | 0.0020 |
 Hepatocyte growth factor-like protein | MSP | P26927 | 4485 | MST1 | 0.7340 |
 Protein S100-A9 | calgranulin B | P06702 | 6280 | S100A9 | 0.0156 |
 Serum amyloid A-1 protein | SAA | P0DJI8 | 6288 | SAA1 | 0.5095 |
 Alpha-1-antichymotrypsin | a1-Antichymotrypsin | P01011 | 12 | SERPINA3 | 0.2672 |
 Superoxide dismutase [Cu–Zn] | SOD | P00441 | 6647 | SOD1 | 0.9448 |
 Serotransferrin | Transferrin | P02787 | 7018 | TF | 0.0185 |
 Transketolase | Transketolase | P29401 | 7086 | TKT | 0.8309 |