Fig. 6

Overexpressed miR-424 delivered by MSC-derived EVs represses the tumorigenesis and angiogenesis of ovarian cancer in vivo. The nude mice used for the following detections were injected with cells transfected with lv-NC, lv-miR-424 mimic, EVs-mimic NC and EVs-miR-424 mimic. a The xenografted tumors from nude mice after different treatments. b The volume of tumors from nude mice after different treatments. c The weight of tumors from nude mice after different treatments. d The expression of miR-424 in EVs of serum from nude mice after different treatments, as detected by RT-qPCR. e The protein expression of MYB and VEGF in tumor tissues from nude mice after different treatments determined by Western blot analysis, with protein bands assessed. f The MVD of tumor tissues from nude mice after different treatments detected by MVD measurement. *p < 0.05 compared with lv-EVs-mimic NC treatment, ^#p < 0.05 compared with lv-NC treatment. The data above were measurement data and were presented as sample mean ± standard deviation. Data among multiple groups were compared by one-way ANOVA, and the data of tumor volume were analyzed by repeated measurement ANOVA, n = 15