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Table 1 Baseline characteristics of IDH-wildtype GBM and its derived TSs

From: Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres

 

Tumor samples (n = 58)

GBM TSs (n = 23)

p-value*

Age

58.9 ± 12.4

59.7 ± 11.0

0.78

Sex

  

0.66

 Male

33

15

 

 Female

25

8

 

MGMT promoter

  

0.67

 Methylation

23

11

 

 Unmethylation

35

12

 

TP53

  

0.027

 Mutant

28

16

 

 Wildtype

30

4

 

 Unknown

 

3

 

TERT promoter

  

0.30

 Mutant

44

18

 

 Wildtype

14

2

 

 Unknown

 

3

 

PTEN

  

0.80

 Mutant

31

12

 

 Wildtype

27

8

 

 Unknown

 

3

 

EGFR

  

0.99

 Alterations

28

9

 

 Wildtype

30

11

 

 Unknown

 

3

 
  1. All samples are primary glioblastomas or its derived TSs. Presentation of age with mean ± standard deviation
  2. GBM: glioblastoma, IDH: isocitrate dehydrogenase, TSs: GBM tumorspheres, MGMT: O-6-methylguanine-DNA methyltransferase, TP53: tumor protein p53 gene mutation, TERT: telomerase reverse transcriptase, PTEN: phosphatase and tensin homolog, EGFR: epidermal growth factor receptor
  3. * p-value compared IDH-WT GBM tumor samples and GBM TSs (GSC11 or normal human astrocyte are excluded from this table)
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Journal of Translational Medicine

ISSN: 1479-5876

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