Fig. 1

Gene expression of TERT and TP53 are associated in the multiple databases. a Correlation of two genes in the Severance RNAseq of IDH-WT GBM tissue by TP53 mutation status (Tumor with TP53 mutation status, n = 58, Pearson correlation). b TERT gene expression by the mutation status of TERT promoter. c Correlation TCGA GBM in the primary and recurrent tumor. d TERT and TP53 in the GBM tumorsphere RNAseq (TS with TP53 mutation status, n = 20). e Single cell RNAseq of a representative GBM TS with multiple clusters (Modularity optimizer 1.3.0, Resolution = 0.5, Number of communities = 7). GBM TS was isolated with serum free B27 medium (see “Methods” for details)