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Table 3 Multivariate linear regression factors associated with duration of mechanical ventilation (variation in minutes) in the first 30 days of hospitalization among 63 patients with severe pneumonia (LYMPHONIE study, 2018-2020)

From: The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

Model Variable effect GM-CSF model 1 GM-CSF model 2 CXCL10 model 1 CXCL10 model 2 IL-10 model 1 IL-10 model 2
Mean diff (± SE) p Mean diff ±SE p Mean diff ±SE p Mean diff ±SE p Mean diff ±SE p Mean diff ±SE p
GM-CSF (per 1 pg/ml increase) 22.1 (± 8.4) 0.011 32.7 (± 7.5) <.0001   NE    NE    NE    NE   
CXCL10 (per 100 pg/ml increase)   NE    NE    24.2 (± 23.2) 0.302 46.4 (± 23.1) 0.049    NE    NE   
IL-10 (per 10 pg/ml increase)   NE    NE     NE    NE   13.7 (± 10.8) 0.208 23.8 (± 11.1) 0.036
Age (per additional year) −19.0 (± 121.2) 0.876 42.0 (± 121.1) 0.730 −1.8 (± 127.0) 0.989 69.3 (± 135.1) 0.61 −29.9 (± 129.4) 0.8178 30.19 (± 137.4) 0.827
COVID-19 (Yes vs No) 8,149.7 (± 3200.6) 0.014 7,633.2 (± 3142.4) 0.018 1,113 (± 3,142.4) 0.001 11.7 (± 3.3) 0.0009 10.7 (± 3,2) 0.001 11,12 (± 3,341.8) 0.002
SOFA (for each additional point) 1,667.8 (± 542.5) 0.003   NE    2,080.9 (± 551.14) 0.0004   NE   2,139.4 (± 524) 0.0001   NE   
PaO2:FiO2 (per 1 point increase) NE    90.2 (± 27.8) 0.002 NE   82.6 (± 31.4) 0.011 NE   93.0 (± 30.8) 0.004
R2 41.46%    42.4%    35.61%    28.33%    36.18%    29.0%   
  1. GM-CSF Granulocyte–macrophage colony-stimulating factor, IL interleukin, CXCL C-X-C motif chemokine ligand, NE not entered in the model, SOFA Sequential Organ Failure Assessment, PaO2:FiO2 arterial pressure of oxygen/oxygen inspiratory fraction, SE standard error