The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma

Table 3 Differences in methylation sites of FOXO3 and TP53 in LOA patients

CpG Site	CpG island	Mean difference methylation	FDR adjusted p-value	p-value (logit)	AUC	p-value (AUC)
chr6:108879441	FOXO3-1	− 0.39%	< 0.001*	0.013*	0.925	< 0.001*
chr6:108879922	FOXO3-1	− 0.22%	0.043*	0.026*	0.895	< 0.001*
chr6:108880271	FOXO3-2	− 0.08%	0.005*	0.048*	0.887	< 0.001*
chr6:108882982	FOXO3-2	− 11.70%	0.025*	0.041*	0.887	< 0.001*
chr6:108882977	FOXO3-2	− 11.39%	0.023*	0.035*	0.878	< 0.001*
chr6:108882964	FOXO3-2	− 11.00%	0.038*	0.046*	0.880	< 0.001*
chr6:108882825	FOXO3-2	− 10.72%	0.034*	0.049*	0.885	< 0.001*
chr17:7591672	TP53-1	− 0.31%	0.009*	0.043*	0.898	< 0.001*

Differential methylation analysis was conducted between LOA patients and HCs in peripheral blood. The method of Benjamin Hochberg was used to control the false discovery rate (FDR), *p < 0.05; Age factor was adjusted in the logistic regression analysis

ISSN: 1479-5876