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Table 1 Baseline characteristics of the study participants

From: Respiratory microbiome profiles differ by recent hospitalization and nursing home residence in patients on mechanical ventilation

  Pneumonia Non-pneumonia p value NHAI Non NHAI p value
n = 41 n = 19 n = 24 n = 36
Agea 73 (61–79) 76 (59–81) 0.744 78 (72–85) 71 (57–77) 0.004
Maleb 30 (73.2%) 12 (63.2%) 0.431 15 (62.5%) 27 (75.0%) 0.391
ARDS 8 (19.5%) 0 (0%) 0.047 4 (16.7%) 4 (11.1%) 0.702
Pneumonia     23 (95.8%) 19 (52.8%) < 0.001
Charlson Comorbidity Indexa 3 (1–4)   0.085 3 (2.3–5.0) 1.5 (0–2.8) < 0.001
Cause of intubation    < 0.001    < 0.001
 Cardiac arrest 1 (2.4%) 3 (15.8%)   0 (0.0%) 4 (11.1%)  
 Neurological distress 5 (12.2%) 13 (68.4%)   1 (4.2%) 17 (47.2%)  
 Post-operative status 0 (0%) 1 (5.3%)   0 (0.0%) 1 (2.8%)  
 Respiratory 35 (85.4%) 2 (10.5%)   23 (95.8%) 14 (38.9%)  
PaO2/FiO2 ratio 212 (133.5–299) 431 (321–458) < 0.001 222 (131.3–301.0) 323 (184.3–442.5) 0.022
Severity       
 APACHE II scorea 20 (16–24) 22 (17–25) 0.202 20.5 (16.3–24.0) 21 (17–25) 0.634
 SOFA scorea 7 (6–9) 6 (4–9) 0.117 7 (6–9) 7 (5–9) 0.569
GCSa 8 (6–11) 6 (5–9) 0.074 8.5(6.0–10.8) 7.5 (6–9) 0.303
Extubation success in 3 weeks 23 (56.1%) 11 (57.9%) 0.999 14 (58.3%) 20 (55.6%) 0.999
28-day all-cause mortality 12 (29.3%) 6 (31.6%) 0.999 7 (29.2%) 11 (30.6%) 0.999
Final hospital mortality 19 (46.3%) 6 (31.7%) 0.4 11 (45.8%) 14 (38.9%) 0.606
MV durationa 13 (8–18) 10 (7–16) 0.335 13 (8–17.5) 10 (7.0–16.8) 0.384
CRP (mg/dl) 133 (45–213.5) 21 (5–132) 0.008 124.5 (62.8–192.0) 94 (8.0–194.0) 0.127
  1. NHAI nursing-home- and hospital-associated infections, ARDS acute respiratory distress syndrome, APACHE II Acute Physiology and Chronic Health Evaluation II, SOFA Sequential Organ Failure Assessment, GCS Glasgow Coma Scale, MV mechanical ventilation, CRP C-reactive protein
  2. a Median (interquartile range)
  3. b Frequency (%)