Table 1 Severe neurological symptoms among different viral infections

Frequency

2.8% (6/214) patients with acute cerebrovascular disease, Wuhan China [1]

13.8% (8/58) required intensive care, France [13]

Globally, 93 patients with encephalopathy; 19 patients with Guillain-Barré syndrome; 8 cases with encephalitis have been reported [14]

2.4% (5/206) with large-vessel stroke, Singapore [2]

5.3% (4/76) with neuromuscular symptoms, Taiwan [5]

9.1% (5/55) with severe neurological symptoms, Iran [4]

Onset of Neurologic manifestations

Can be both early and late onset of neurological manifestations [3]

Two to three weeks after the onset of SARS [2, 5]

Within 7 days

Common neurological manifestations in severe cases

Impaired consciousness; Acute cerebrovascular disease, Skeletal muscle injury

Polyneuropathy, encephalitis, and aortic ischemic stroke

Seizures, encephalopathy and encephalitis

Prognosis

More patients have neurologic disorders in severe subtype with poor outcome

Poor

More children than adults were identified to have neurologic injury with poor outcome [7]

Possible mechanism

The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure [11]

ACE2 [11] and immune injury may play a role

Direct infection, hypoxia and metabolite dysfunction may be more significant [12]