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Table 1 Severe neurological symptoms among different viral infections

From: Comparing COVID-19-linked neurological complications with other viral infections

Neurologic disorders COVID-19 SARS-CoV-2 infection 2019 SARS SARS-CoV-1 infection 2003 INFLUENZA H1N1 infection 2009
Frequency 2.8% (6/214) patients with acute cerebrovascular disease, Wuhan China [1]
13.8% (8/58) required intensive care, France [13]
Globally, 93 patients with encephalopathy; 19 patients with Guillain-Barré syndrome; 8 cases with encephalitis have been reported [14]
2.4% (5/206) with large-vessel stroke, Singapore [2]
5.3% (4/76) with neuromuscular symptoms, Taiwan [5]
9.1% (5/55) with severe neurological symptoms, Iran [4]
Onset of Neurologic manifestations Can be both early and late onset of neurological manifestations [3] Two to three weeks after the onset of SARS [2, 5] Within 7 days
Common neurological manifestations in severe cases Impaired consciousness; Acute cerebrovascular disease, Skeletal muscle injury Polyneuropathy, encephalitis, and aortic ischemic stroke Seizures, encephalopathy and encephalitis
Prognosis More patients have neurologic disorders in severe subtype with poor outcome Poor More children than adults were identified to have neurologic injury with poor outcome [7]
Possible mechanism The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure [11] ACE2 [11] and immune injury may play a role Direct infection, hypoxia and metabolite dysfunction may be more significant [12]