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Table 4 Incidence and adjusted hazard ratio of Parkinson's disease stratified by medication in patients with ankylosing spondylitis

From: Positive association of Parkinson’s disease with ankylosing spondylitis: a nationwide population-based study

Medication exposed

N

Event

PY

Rate

Crude HR

(95% CI)

Adjusted HR†

(95% CI)

Without ankylosing spondylitis

25,760

210

170,858

1.23

1 (Reference)

1 (Reference)

Ankylosing spondylitis

 Without Immunosuppressant therapy

5158

92

34,682

2.65

2.16 (1.69, 2.76)***

1.70 (1.32, 2.18)***

 With Immunosuppressant therapy

1282

10

8569

1.17

0.95 (0.50, 1.79)

2.40 (1.26, 4.56)** 

 Without Biological therapy

6403

102

43,029

2.37

1.93 (1.53, 2.45)***

1.75 (1.38, 2.23)***

 With

Biological therapy

37

0

223

 

–

–

  1. Rate per 1000 person-year; Crude HR, relative hazard ratio
  2. † Model was adjusted for age and comorbidities of diabetes, hypertension, hyperlipidemia, stroke, depression, coronary artery disease, head injury, and chronic kidney disease and medication of NSAIDs
  3. *p < 0.05, **p < 0.01, ***p < 0.001
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Journal of Translational Medicine

ISSN: 1479-5876

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