Fig. 4From: Heparanase and the hallmarks of cancerTargeting HPSE within the TME may promote tumour growth. The indiscriminate targeting of HPSE within the TME may compromise tumour immunity by inhibiting immune cells responsible for tumour immunosurveillance and anti-tumour activity. It is therefore important that the precise role of HPSE within each tumour setting is thoroughly analysed prior to the administration of HPSE inhibitorsBack to article page