Table 1 Comparison of two most frequently utilized exosome isolation methods for clinical utility

Mechanism of exosome separation

Physical features of exosomes (size, shape and density), the exerted centrifugal force, and the viscosity of the solvent

Particle size and MWCO of the utilized filter membrane

Recovery

I

H

Purity

H

L

Specificity

I

L

Sample volume

I

H

Efficiency

I

I

Time

H

H

Cost

L

I

Complexity

I

L

Functionality of exosomes

I

I

Scalability

I

H

Advanced equipment

I

L

References

[113,114,115,116,117]

[118,119,120,121]