Fig. 5

Utility of PDX genomic data and in vivo drug tests for clinical implications. a ESR1 mutation site and its domain in the IMX-158 sample. b CNV in the IMX-158 sample. c PET scan of the donor of the IMX-158 sample. Baseline indicates before the initiation of palbociclib and fulvestrant treatment. The best response was observed four months after initiation. White arrows indicate hypermetabolic lesions in the liver and pelvic bone. d CNV in the X89 sample. e ATR mutation site and its domain in the X89 sample. g The X89 PDX model was treated with the ATR inhibitor AZD6738 for 4 weeks. The tumor volumes are presented as graphs