Fig. 4

Significant features in the HR + PDX model. a ESR1 mutations in the HR + PDX model. b CCND1 amplification was analyzed by Fisher’s exact test in all of our PDX models. c The FPKM values of the CCND1 gene were analyzed, and those from ESR1-mutated samples and wild-type samples were compared. d Mutation signature analysis was performed, and the signatures were clustered. The signatures depict the 1st and 2nd highest cosine similarity. e, f APOBEC3B expression is presented as its FPKM value by subtype (e) or the PIK3CA gene mutation (f)