Fig. 1

UbMPO regulates IFNγ and IL-17A production of CD4 ⁺ lymphocytes from SLE patients cocultured with LPS activated DCs with UbMPO or rhMPO. Increased production of proinflammatory cytokines, IFNγ (a) and IL-17A (b) was documented for CD4 ⁺ lymphocytes from SLE patients upon stimulation with UbMPO, meanwhile no differences were found in the IL-4 production (c). A differential proliferative response was found between SLE and healthy controls, with increased activation (d) and proliferation (e) (no significative) from the lupus samples and decreased proliferation from healthy controls (Additional file 1: Figure S3) towards UbMPO stimulation. *p < 0.05