Fig. 1

Differential expression of in- and decreased circulating inflammatory proteins when comparing QFS to HC, CFS to HC, and QFS to CFS. Volcanoplots showing differential expression of in- and decreased circulating inflammatory proteins when comparing, a QFS (n = 31) to HC (n = 50), b CFS (n = 50) to HC (n = 50) and c QFS (n = 31) tot CFS (n = 50). A total of 92 circulating inflammatory markers were measured using Proximity Extension Essay. Significantly in- and decreased proteins are shown in red and statistical significance was attained if FDR adjusted P ≤ 0.05. Coefficients of in- and decreased circulating inflammatory proteins are shown in Table 2. QFS Q fever fatigue syndrome, HC healthy controls, CFS chronic fatigue syndrome