Fig. 3

Human counterpart hotspots in cell line development. a The presented oncoprint reveals patterns and correlations of the different cell lines 328 and A7450 T1 M1 with regard to tumor suppressive functions, tumor initiation, and progression. An overview of the non-synonymous alterations in genes of interest (rows) affecting the cell lines (columns) is provided with this way of visualization. b Prevalence and hotspot regions in Arid1a, Tcerg1, and Wwox. The colored regions show known gene/ protein domains, while the other regions are represented in dark grey. The missense mutations are depicted as a red lollipop in the cell lines, whereby each lollipop label shows an amino acid change with its corresponding location