Fig. 3

a Depression: T-score (with 95% CIs) for PROMIS-43 Depression subdomain, and PHQ-9—comparisons by dosing subgroups between Baseline, Week 2, and Week 4 measurements. Dose −: (N = 16) dose decreased at Week 2 study visit; Dose + : (N = 28) dose increased at Week 2 study visit. b Anxiety: T-score (with 95% CIs) for PROMIS-43 Anxiety subdomain, and GAD-7—comparisons by dosing subgroups between Baseline, Week 2, and Week 4 measurements. Dose −: (N = 16) dose decreased at Week 2 study visit; Dose + : (N = 28) dose increased at Week 2 study visit