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Table 3 Subgroup interaction analyses in preterm infants with type 1 ROP, type 2 ROP

From: Effect of early prophylactic low-dose recombinant human erythropoietin on retinopathy of prematurity in very preterm infants

Type 1 ROP

Type 2 ROP

Type 1 or Type 2 ROP

Characteristic

Control, n = 28 No. (%)

rhEPO, n = 23 No. (%)

RR (95% CI)

Interaction P value

Control, n = 36 No. (%)

rhEPO, n = 20 No. (%)

RR (95% CI)

Interaction P value

Control, n = 64 No. (%)

rhEPO, n = 43 No. (%)

RR (95% CI)

Interaction P value

Sex

   

0.391

   

0.022

   

0.021

 Boys

19/538 (3.5)

10/549 (1.8)

0.98 (0.96–1.00)

 

23/538 (4.3)

10/549 (1.8) *

0.98 (0.96–1.00)

 

42/538 (7.8)

20/549 (3.6) *

0.96 (0.93–0.99)

 

 Girls

9/340 (2.6)

13/364 (3.6)

1.01 (0.98–1.04)

 

13/340 (3.8)

10/364 (2.7)

0.99 (0.96–1.02)

 

22/340 (6.5)

23/364 (6.3)

1.00 (0.96–1.04)

 

Gestational age**

   

0.295

   

0.016

   

0.012

  < 28 weeks

6/50 (12.0)

7/65 (10.8)

0.99 (0.86–1.13)

 

3/50 (6.0)

8/64 (12.5)

1.07 (0.96–1.20)

 

9/50 (18.0)

15/64 (23.4)

1.07 (0.89–1.30)

 

 28–296/7 weeks

8/326 (2.5)

10/362 (2.8)

1.00 (0.98–1.03)

 

16/326 (4.9)

4/362 (1.1) *

0.96 (0.94–0.99)

 

24/326 (7.4)

14/362 (5.3)

0.96 (0.93–1.00)

 

 30–32 weeks

14/502 (2.8)

6/485 (1.2)

0.98 (0.97–1.00)

 

17/502 (3.4)

8/485 (1.6)

0.98 (0.96–1.00)

 

31/502 (6.2)

14/485 (2.9) *

0.97 (0.94–0.99)

 

Birth weight**

   

0.275

   

0.013

   

0.008

  < 1000 g

5/52 (9.6)

10/63 (15.9)

1.07 (0.94–1.24)

 

7/52 (13.5)

8/63 (12.7)

0.99 (0.86–1.14)

 

12/52 (23.1)

18/63 (28.6)

1.07 (0.87–1.34)

 

 1000–1499 g

16/544 (2.9)

12/644 (1.9)

0.99 (0.97–1.01)

 

23/544(4.2)

8/644 (1.2) *

0.97 (0.95–0.99)

 

39/544 (7.2)

20/644 (3.1) *

0.96 (0.93–0.98)

 

  ≥ 1,500 g

7/282 (2.5)

1/205 (0.5)

0.98(0.96–1.00)

 

6/282 (2.1)

4/205 (2.0)

1.00 (0.97–1.02)

 

13/282 (4.6)

5/205 (2.4)

0.98 (0.95–1.01)

 
  1. Probability value is for interaction analysis in subgroups using the Mantel–Haenszel test. p < 0.05 was considered statistically significant
  2. CI, confidence interval; rhEPO, recombinant human erythropoietin
  3. *p < 0.05, rhEPO group vs. control group using Fisher exact test;
  4. **p < 0.01, comparing ROP outcomes with gestational age, birth weight using Fisher exact test
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Journal of Translational Medicine

ISSN: 1479-5876

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