Fig. 8

GBM cases with high risk scores exhibited enhanced immunosuppression. a Risk scores were positively associated with stromal scores and immune scores, whereas they were negatively correlated with tumor purity in TCGA and CGGA datasets. b, c Effect of the risk signature on the enrichment of immune cells. Risk scores were positively correlated with eosinophils, macrophages, neutrophils, and regulatory T cells, but negatively correlated with central memory T cells (Tcm) and helper T cells (Th) in the CGGA. d Risk scores were significantly positively correlated with immunosuppressive gene set scores in the CGGA. ****P < 0.0001. e The circle plot showed the relation between risk score and eight immunosuppressive effectors in CGGA