Table 3 Genotype and allele distribution of SNPs in PTPN22 (rs2476601), PADI4 (rs2240340) and CTLA4 (rs3087243) among RA patients and controls
From: rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis—a possible interface?
Variable | Control probands (without RA) | RA patients | p value | |||||
|---|---|---|---|---|---|---|---|---|
No/ level 1 PD n = 95 | Level 2 PD N = 161 | All n = 111 | No/ level 1 PD n = 85 | Level 2 PD n = 26 | Prevalence of RA | Prevalence of PD within RA group | Comorbidity PD and RA | |
I | II | III | IV | V | I. vs. III | IV. vs. V | I. vs. V | |
PTPN22, rs2476601 | ||||||||
CC genotype (%) | 78.9 | 74.5 | 60.4 | 67.1 | 38.5 | |||
CT genotype (%) | 19.0 | 23.5 | 36.0 | 29.4 | 57.7 | |||
TT genotype (%) | 2.1 | 1.9 | 3.6 | 3.5 | 3.8 | |||
C allele (%) | 88.4 | 86.3 | 78.4 | 81.8 | 67.3 | |||
T allele (%) | 11.6 | 13.7 | 21.6↑ | 18.2 | 32.7↑ | < 0.001 | 0.043 | < 0.001 |
PADI4, rs2240340 | ||||||||
CC genotype (%) | 51.6 | 38.5 | 36.0 | 37.6 | 30.8 | |||
CT genotype (%) | 11.6 | 27.3↑ | 14.5 | 9.4 | 30.7↑ | |||
TT genotype (%) | 36.8 | 34.2 | 49.5 | 52.9 | 38.5 | |||
C allele (%) | 57.4 | 52.2 | 43.2 | 42.4 | 46.2 | |||
T allele (%) | 42.6 | 47.8 | 56.8↑ | 57.6 | 53.8↑ | 0.006 | 0.746 | 0.200 |
CTLA4, rs3087243 | ||||||||
GG genotype (%) | 37.9 | 33.5 | 44.1 | 48.2 | 30.8 | |||
AG genotype (%) | 50.5 | 47.2 | 44.2 | 37.6 | 65.4 | |||
AA genotype (%) | 11.6 | 19.3 | 11.7 | 14.1 | 3.8↓ | |||
G allele (%) | 63.2 | 57.1 | 66.2 | 67.1 | 63.5 | |||
A allele (%) | 36.8 | 42.9 | 33.8 | 32.9 | 36.5 | 0.586 | 0.755 | 1.000 |