From: rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis—a possible interface?
Variable | Control probands (without RA) | RA patients | p value** | |||
---|---|---|---|---|---|---|
No/level 1 PD n = 95 | Level 2 PD* N = 161 | All n = 111 | No/ level 1 PD n = 85 | Level 2 PD* n = 26 | ||
Demographical and anamnestic parameters | ||||||
Age, years (Median (25–75th IQR)) | 43.0 (38.0/51.0) | 45.0 (38.0/52.0) | 56.0 (48.0/63) | 56.0 (47.0/63.0) | 56.5 (50.0/64.5) | < 0.001 |
Male gender (%) | 51.6 | 37.3 | 28.8 | 23.5 | 46.2 | 0.001 |
Current smoking (%) | 21.1 | 29.4 | 23.4 | 18.8 | 38.5 | 0.003 |
Periodontal conditions (Median (25–75th IQR) | ||||||
Plaque index (%) | 39.0 (28.6/59.3) | 57.0 (38.0/82.0) | 35.7 (11.5/66.7) | 27.0 (7.25/58.55) | 64.1 (37.6/84.1) | 0.176 |
Bleeding on probing/tooth (%) | 42.0 (23.1/63.0) | 82.5 (56.0/100.0) | 36.4 (18.2/69.6) | 32.0 (16.7/63.25) | 58.6 (32.4/89.8) | 0.941 |
Probing depth, mm | 2.52 (2.27/2.76) | 5.29 (4.52/6.4) | 3.0 (2.7/3.7) | 2.8 (2.6/3.2) | 4.3 (3.78/4.96) | < 0.001 |
Clinical attachment loss, mm | 2.8 (2.55/3.14) | 6.1 (5.27/7.16) | 3.4 (2.9/4.3) | 3.1 (2.8/3.7) | 5.15 (4.5/6.05) | < 0.001 |
Missing teeth (except 8th) | 2.0 (0/4.0) | 3.0 (1.0/6.0) | 5.0 (2.0/10.0) | 4.0 (1.0/10.0) | 8.5 (5.0/15.25) | < 0.001 |