Table 3 Adjusted association of fibrinogen and Lp(a) categories with clinical outcomes
Risk factor | Tertile/range | KM rates (%) | Hazard ratio | (95% CI) | p value |
|---|---|---|---|---|---|
Lp(a) categories | Total | Â | Â | Â | 0.001 |
|  | Lp(a)-L (< 10) | 3.5 | Reference |  | |
|  | Lp(a)-M (10–29.9) | 5.3 | 1.531 | 1.128–2.079 | 0.006 |
|  | Lp(a)-H (≥ 30) | 5.6 | 1.786 | 1.315–2.426 |  < 0.001 |
Fibrinogen categories | Total | Â | Â | Â | 0.002 |
|  | Fib-L(< 2.84) | 4.0 | Reference |  | |
|  | Fib-M(2.85–3.42) | 4.4 | 1.001 | 0.726–1.379 | 0.996 |
|  | Fib-H(≥ 3.43) | 6.1 | 1.558 | 1.162–2.089 | 0.003 |
Combined categories | Total | Â | Â | Â | 0.002 |
|  | G1(Lp(a)-L + Fib-L) | 3.3 | Reference |  | |
|  | G2(Lp(a)-L + Fib-M) | 3.5 | 1.203 | 0.687–2.107 | 0.518 |
|  | G3(Lp(a)-L + Fib-H) | 4.0 | 1.476 | 0.831–2.619 | 0.184 |
|  | G4(Lp(a)-M + Fib-L) | 4.1 | 1.482 | 0.846–2.596 | 0.169 |
|  | G5(Lp(a)-M + Fib-M) | 4.9 | 1.511 | 0.866–2.636 | 0.146 |
|  | G6(Lp(a)-M + Fib-H) | 7.0 | 2.307 | 1.409–3.777 | 0.001 |
|  | G7(Lp(a)-H + Fib-L) | 4.8 | 1.912 | 1.085–3.369 | 0.025 |
|  | G8(Lp(a)-H + Fib-M) | 5.4 | 1.707 | 0.984–2.962 | 0.057 |
|  | G9(Lp(a)-H + Fib-H) | 7.2 | 2.656 | 1.628–4.333 |  < 0.001 |