Table 2 Association of fibrinogen and Lp(a) categories with clinical outcomes
Risk factor | Tertile/range | KM rates(%) | Hazard ratio | (95% CI) | p value |
|---|---|---|---|---|---|
Lp(a) categories | Total (mg/dL) |  |  |  |  < 0.001 |
|  | Lp(a)-L (< 10) | 3.5 | Reference |  | |
|  | Lp(a)-M (10–29.9) | 5.3 | 1.468 | 1.142–1.886 | 0.003 |
|  | Lp(a)-H (≥ 30) | 5.6 | 1.580 | 1.227–2.033 |  < 0.001 |
Fibrinogen categories | Total (g/L) |  |  |  |  < 0.001 |
|  | Fib-L(< 2.84) | 4.0 | Reference |  | |
|  | Fib-M(2.85–3.42) | 4.4 | 1.123 | 0.867–1.455 | 0.380 |
|  | Fib-H(≥ 3.43) | 6.1 | 1.631 | 1.282–2.074 |  < 0.001 |
Combined categories | Total |  |  |  |  < 0.001 |
|  | G1(Lp(a)-L + Fib-L) | 3.3 | Reference |  | |
|  | G2(Lp(a)-L + Fib-M) | 3.5 | 1.091 | 0.697–1.707 | 0.704 |
|  | G3(Lp(a)-L + Fib-H) | 4.0 | 1.234 | 0.771–1.977 | 0.381 |
|  | G4(Lp(a)-M + Fib-L) | 4.1 | 1.164 | 0.741–1.828 | 0.509 |
|  | G5(Lp(a)-M + Fib-M) | 4.9 | 1.406 | 0.914–2.162 | 0.121 |
|  | G6(Lp(a)-M + Fib-H) | 7.0 | 2.135 | 1.446–3.152 |  < 0.001 |
|  | G7(Lp(a)-H + Fib-L) | 4.8 | 1.348 | 0.849–2.140 | 0.206 |
|  | G8(Lp(a)-H + Fib-M) | 5.4 | 1.578 | 1.026–2.426 | 0.038 |
|  | G9(Lp(a)-H + Fib-H) | 7.2 | 2.215 | 1.506–3.257 |  < 0.001 |