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Table 1 Univariate and multivariate Cox regression analyses of the 21-gene signature and OS in the training set (early-stage LUAD)

From: Development and validation of a robust immune-related prognostic signature in early-stage lung adenocarcinoma

Variables Patients (N) Univariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p value
GSE30219
 Age  > 65/ ≤ 65 23/59 1.765 0.946–3.295 7.42E−02 2.36 1.179–4.724 1.53E−02
 Gender Male/female 64/18 1.148 0.532–2.478 7.24E−01    
 T stage T2/T1 12/69 2.046 1.019–4.107 4.40E−02 0.982 0.352–1.94 9.63E−01
 Risk score High/low 34/48 4.308 2.287–8.114 6.16E−06 5.012 2.498–10.058 5.75E−06
GSE31210
 Age  > 65/ ≤ 65 47/157 2.779 1.349–5.724 5.59E−03 3.172 1.445–6.964 4.01E−03
 Gender Male/female 95/109 1.686 0.818–3.476 1.57E−01 1.033 0.347–3.078 9.54E−01
 Stage II/I 42/462 4.297 2.092–8.828 7.21E−05 2.444 1.152–5.186 1.99E−02
 Smoking Yes/no 99/105 1.908 0.918–3.966 8.35E−02 1.726 0.565–5.271 3.38E−01
 ALK fusion  ±  7/197 1.057 0.144–7.777 9.56E−01    
 EGFR mutation  ±  116/88 0.46 0.222–0.956 3.76E−02 1.658 0.512–5.375 3.99E−01
 KRAS mutation  ±  19/185 0.992 0.3–3.282 9.89E−01    
 Triple negative Yes/no 62/142 0.436 0.212–0.894 2.34E−02 0.543 0.174–1.698 2.94E−01
 MYC copy High/low 16/187 0.767 0.183–3.22 0.716942752    
 Risk score High/low 81/123 11.914 4.151–34.193 4.10E−06 8.817 2.864–27.14 1.48E−04
GSE50081
 Age  > 65/ ≤ 65 87/40 1.455 0.774–2.735 2.44E−01    
 Gender Male/female 65/62 1.41 0.807–2.463 2.28E−01    
 Stage II/I 35/92 2.443 1.383–4.316 2.10E−03 1.905 1.068–3.399 2.90E−02
 T stage T2/T1 82/30 2.435 1.214–4.883 1.22E−02 1.625 0.785–3.365 1.91E−01
 Smoking Yes/no 92/23 1.682 0.75–3.776 2.07E−01    
 Risk score High/low 72/55 3.632 1.897–6.953 9.95E−05 2.736 1.373–5.455 4.24E−03
Combined data set
 Age  > 65/ ≤ 65 157/256 2.314 1.621–3.304 3.82E−06 2.414 1.686–3.456 1.49E−06
 Gender Male/female 224/189 1.574 1.081–2.291 1.80E−02 1.582 1.084–2.307 1.73E−02
 Stage II/I 90/323 2.79 1.934–4.026 4.08E−08 2.065 1.42–3.004 1.49E−04
 Risk score High/low 270/143 3.153 1.981–5.016 1.26E−06 3.005 1.863–4.846 6.44E−06