Fig. 6

Analysis of the immune cell composition of the analyzed RCCs. Observed presence of different intra-tumoral immune cells among different categories of tumoral CREB expression (staining intensity). While the mean absolute numbers of four high power fields did not significantly vary for CD3+ (a), CD4+ (c) and CD56+ immune cells (p = 0.3, p = 0.11, p = 0.17, p = 0.12), the presence of FOXP3⁺ cell increased significantly with higher CREB expression (p = 0.0018), although the absolute cell number remains very low. CD8+ (b) expression also significantly vary (p = 0.011), but is hard to interprete when looking at the distribution of positive cells over the CREB staining categories